Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

31.9K
Overview
31.9K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.1K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.1K
Hypersensitivities01:30

Hypersensitivities

6.8K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
6.8K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.0K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.0K
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

1.7K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles.

PloS one·2022
Same author

Rational discovery of a cancer neoepitope harboring the KRAS G12D driver mutation.

Science China. Life sciences·2021
Same author

Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy.

Oncoimmunology·2021
Same author

Editorial: Nomenclature - Avoiding Babylonian Speech Confusion in Present Day Immunology.

Frontiers in immunology·2020
Same author

Chronic Urticaria in Children: an Update on Diagnosis and Treatment.

Current allergy and asthma reports·2020
Same author

Keeping Allergen Names Clear and Defined.

Frontiers in immunology·2019

Related Experiment Video

Updated: Jan 4, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.9K

Advances in aeroallergen immunotherapy.

Sanny K Chan1

  • 1Department of Pediatrics, National Jewish Health, Division of Allergy and Immunology, Denver, Colorado, USA.

Current Opinion in Pediatrics
|November 7, 2019
PubMed
Summary

Allergy immunotherapy offers an effective treatment for allergic rhinoconjunctivitis by modulating immune dysfunction. This approach shows promise in preventing asthma development in children with allergic rhinitis.

Area of Science:

  • Immunology
  • Allergy Research

Background:

  • Allergic rhinoconjunctivitis is a prevalent allergic disease.
  • Immune system dysfunction leads to reactions against harmless environmental molecules like pollen and pet dander.
  • This condition results in a significant, often underestimated, disease burden.

Purpose of the Study:

  • To review the role of allergy immunotherapy in managing allergic diseases.
  • To highlight advances in peptide-based allergen immunotherapy.
  • To examine the potential of immunotherapy in preventing asthma in children.

Main Methods:

  • Review of current literature on allergic rhinoconjunctivitis and immunotherapy.
  • Analysis of molecular component testing and its predictive value.
  • Evaluation of studies on the long-term effects of allergy immunotherapy in pediatric populations.

More Related Videos

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.9K
Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

23.9K

Related Experiment Videos

Last Updated: Jan 4, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.9K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.9K
Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

23.9K

Main Results:

  • Individual molecular component testing can enhance the predictive value of blood sIgE and clinical symptoms.
  • Advances in peptide-based immunotherapy are based on identifying key symptom-inducing allergenic proteins.
  • Consistent reports indicate that allergy immunotherapy for children with symptomatic allergic rhinitis can prevent asthma onset.

Conclusions:

  • Allergy immunotherapy is an effective disease-modulating treatment that addresses underlying immune dysfunction.
  • This therapy is currently underutilized despite its proven benefits.
  • Allergy immunotherapy is likely effective in preventing asthma in children, at least in the short term.