The prebiotic effect of CPP-ACP sugar-free chewing gum
James R Fernando1, Catherine A Butler1, Geoffrey G Adams1
1Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Victoria, Australia.
Journal of Dentistry
|November 7, 2019
Summary
Chewing sugar-free gum with CPP-ACP significantly boosted beneficial oral bacteria like Streptococcus sanguinis. This promotes a healthier oral microbiome and prebiosis, contributing to better dental health.
Area of Science:
- Oral microbiology
- Dental research
- Microbiome analysis
Background:
- The oral microbiome plays a crucial role in dental health.
- Understanding factors that promote beneficial oral bacteria is essential for preventative dentistry.
Purpose of the Study:
- To investigate if chewing gum containing casein phosphopeptide stabilised amorphous calcium phosphate (CPP-ACP) increases beneficial bacterial species in supragingival plaque.
Main Methods:
- A randomized, controlled clinical trial involving 19 participants.
- Participants chewed sugar-free gum with or without CPP-ACP for two weeks.
- Supragingival plaque was analyzed for bacterial composition using 16S rRNA gene sequencing.
Main Results:
- CPP-ACP gum significantly increased proportions of Streptococcus sanguinis (112%), Rothia dentocariosa (127%), Corynebacterium durum (80%), and Streptococcus mitis (55%).
- Promoted species possess alkali-producing enzymes, contributing to a healthier oral environment.
Conclusions:
- Chewing sugar-free CPP-ACP gum promotes prebiosis by increasing health-associated bacterial species.
- This intervention supports oral homeostasis and a healthier supragingival plaque microbiome.
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