Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

413
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
413
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

287
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
287
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

335
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
335

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infarct Zone Circumferential Strain Independently Predicts Left Ventricular Functional Recovery After ST-Segment Elevation Myocardial Infarction: A Multiparametric CMR Study.

Diagnostics (Basel, Switzerland)·2026
Same author

Clinical and Biomarker Predictors of Adverse Left Ventricular Remodeling After First STEMI: Insights into Phenotype Variability Using CMR.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Low-Density Lipoprotein Cholesterol Target Attainment in Lithuania: A Nationwide Analysis of Real-World Health Data.

Medicina (Kaunas, Lithuania)·2025
Same author

Imaging Predictors of Left Ventricular Functional Recovery after Reperfusion Therapy of ST-Elevation Myocardial Infarction Assessed by Cardiac Magnetic Resonance.

Journal of cardiovascular development and disease·2023
Same author

Effect of Short-Term Treatment with Continuous Positive Airway Pressure on Cardiopulmonary Exercise Tolerance, Pulmonary and Cardiac Function in Patients with Obstructive Sleep Apnea.

Medicina (Kaunas, Lithuania)·2023
Same author

Efficacy and safety of vericiguat in patients with heart failure with reduced ejection fraction treated with sacubitril/valsartan: insights from the VICTORIA trial.

European journal of heart failure·2022

Related Experiment Video

Updated: Jan 4, 2026

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

8.0K

CMR Tissue Characterization in Patients with HFmrEF.

Patrick Doeblin1,2, Djawid Hashemi2,3, Radu Tanacli1

  • 1Department of Internal Medicine/Cardiology, German Heart Center Berlin, 13353 Berlin, Germany.

Journal of Clinical Medicine
|November 8, 2019
PubMed
Summary

Heart failure with moderately reduced ejection fraction (HFmrEF) shows reduced systolic function and elevated cardiac MRI markers for fibrosis and inflammation, similar to heart failure with reduced ejection fraction (HFrEF). This highlights HFmrEF as a distinct entity requiring further study.

Keywords:
ECV, fibrosisHFmrEFT1 mappingT2 mappinginflammationstrain

More Related Videos

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.8K
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

20.0K

Related Experiment Videos

Last Updated: Jan 4, 2026

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

8.0K
Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.8K
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

20.0K

Area of Science:

  • Cardiology
  • Medical Imaging
  • Heart Failure Research

Background:

  • Heart failure with moderately reduced ejection fraction (HFmrEF, LV-EF 40-50%) remains poorly understood regarding its characteristics and optimal management.
  • Advanced cardiac magnetic resonance imaging (MRI) provides insights into myocardial function, fibrosis, and inflammation, potentially aiding in HFmrEF characterization and adverse remodeling assessment.

Purpose of the Study:

  • To characterize HFmrEF using cardiac MRI, focusing on myocardial fibrosis and inflammation.
  • To compare cardiac MRI parameters in HFmrEF patients with those in heart failure with preserved ejection fraction (HFpEF), heart failure with reduced ejection fraction (HFrEF), and healthy controls.

Main Methods:

  • Cardiac MRI was performed on 17 HFpEF, 18 HFmrEF, 17 HFrEF patients, and 17 healthy controls.
  • T1 and T2 relaxation time mapping were used to assess myocardial tissue characteristics, and extracellular volume (ECV) was calculated.
  • Global circumferential strain (GCS) and global longitudinal strain (GLS) were derived from cine images to evaluate systolic function.

Main Results:

  • HFmrEF patients exhibited moderately reduced GLS (-15.7 ± 2.1) and GCS (-19.9 ± 4.1), indicative of systolic dysfunction.
  • Native T1 relaxation times were elevated in HFmrEF (1027 ± 40 ms) and HFrEF (1033 ± 54 ms) compared to healthy controls (972 ± 31 ms) and HFpEF (985 ± 32 ms).
  • T2 relaxation times were elevated in HFmrEF (55.4 ± 3.4 ms) and HFrEF (56.0 ± 6.0 ms) versus healthy controls (50.6 ± 2.1 ms); ECV differences were not statistically significant.

Conclusions:

  • HFmrEF demonstrates distinct cardiac MRI findings compared to healthy controls, sharing similarities with HFrEF in terms of myocardial fibrosis and inflammation.
  • Cardiac MRI parameters suggest that HFmrEF exhibits aspects of systolic dysfunction and myocardial tissue changes characteristic of fibrosis and inflammation.