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Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

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Updated: Jul 16, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
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Published on: April 25, 2014

Infarct Zone Circumferential Strain Independently Predicts Left Ventricular Functional Recovery After ST-Segment

Agneta Virbickiene1,2, Olivija Dobiliene2, Arnoldas Leleika2

  • 1Institute of Cardiology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.

Diagnostics (Basel, Switzerland)
|July 15, 2026
PubMed
Summary

Segmental cardiac magnetic resonance imaging parameters, including infarct zone circumferential strain, predict left ventricular functional recovery after ST-segment elevation myocardial infarction (STEMI). These findings improve prognostic accuracy for patients post-primary percutaneous coronary intervention (PCI).

Keywords:
ST-segment elevation myocardial infarctionT1 mappingcardiac magnetic resonancecircumferential strainfeature trackinginfarct sizeleft ventricular remodelingprognosis

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Histological Quantification of Chronic Myocardial Infarct in Rats
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Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Cardiac magnetic resonance (CMR) is crucial for assessing myocardial injury post-ST-elevation myocardial infarction (STEMI).
  • The prognostic value of segmental infarct zone parameters for left ventricular (LV) functional recovery needs further definition.
  • Primary percutaneous coronary intervention (PCI) is a standard STEMI treatment.

Purpose of the Study:

  • To evaluate if segmental infarct zone functional and structural CMR parameters predict LV functional recovery after STEMI treated with primary PCI.
  • To compare the prognostic value of segmental parameters versus global indices.
  • To identify key CMR-derived predictors of adverse LV remodeling.

Main Methods:

  • Prospective single-center study of 93 first STEMI patients post-PCI.
  • CMR assessment at baseline and 6-month follow-up.
  • Comprehensive CMR included cine, feature-tracking strain, T1/T2 mapping, and late gadolinium enhancement (LGE) for infarct size (IS) and microvascular obstruction (MVO).

Main Results:

  • Significant reverse remodeling observed at 6 months: improved LV ejection fraction (LVEF) and decreased LV end-systolic volume and relative IS.
  • Circumferential strain (CS) in the infarct zone was the strongest independent predictor of unfavorable LV functional recovery (OR 8.81, p=0.004).
  • Relative IS (OR 4.02, p=0.045) and infarct zone post-contrast T1 (OR 4.40, p=0.034) also predicted recovery.

Conclusions:

  • Segmental infarct zone characteristics, particularly CS, post-contrast T1, and IS, are clinically relevant predictors of LV functional recovery post-STEMI.
  • Infarct zone CS provides incremental prognostic value beyond structural parameters.
  • These findings highlight the importance of segmental analysis for predicting myocardial recovery and guiding patient management.