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Left Atrial Deformation Parameters After Myocardial Infarction With Low Triiodothyronine Syndrome and Their
Edita Jankauskiene1,2, Neda Jonaitiene1, Martynas Jankauskas2
1Department of Cardiology, Lithuanian University of Health Sciences, Kaunas Clinics, 44307 Kaunas, Lithuania.
Cardiology Research
|March 13, 2026
Summary
Left atrial strain analysis using speckle-tracking echocardiography predicts adverse outcomes in ST-segment elevation myocardial infarction (STEMI) patients. These parameters, especially in low triiodothyronine (T3) syndrome, improve risk stratification for heart failure and major adverse cardiac events.
Area of Science:
- Cardiology
- Echocardiography
- Thyroidology
Background:
- Acute myocardial infarction (AMI) management has improved, but long-term complications like heart failure (HF) and atrial fibrillation (AF) persist.
- Left atrial (LA) function, assessed by speckle-tracking echocardiography (STE), is a sensitive marker of cardiac remodeling.
- This study investigates the prognostic value of LA deformation parameters in ST-segment elevation myocardial infarction (STEMI) patients, particularly concerning low triiodothyronine (T3) syndrome.
Purpose of the Study:
- To evaluate the prognostic significance of LA deformation parameters in STEMI patients.
- To explore the relationship between low T3 syndrome and LA function post-STEMI.
- To identify predictors of long-term adverse outcomes in STEMI survivors.
Main Methods:
- Retrospective analysis of 140 first-onset STEMI patients treated with primary percutaneous coronary intervention.
- Measurement of thyroid hormone concentrations (fT3) within 24 hours of admission, classifying patients into low T3 (n=44) and control (n=96) groups.
- Echocardiography and STE performed within 72 hours and at 6 months, analyzing LA reservoir strain and strain rate parameters; 10-year follow-up for adverse events.
Main Results:
- Low T3 patients were older with higher inflammatory markers and reduced acute LA conduit strain rates.
- After 6 months, LA volume increased more in low T3 patients.
- Reduced LA reservoir strain and conduit strain rate predicted MACEs and AF, respectively; LA conduit strain rate, LA reservoir strain, LA volume index, and LVEF were independent predictors of adverse outcomes.
Conclusions:
- STE-derived LA deformation parameters offer valuable prognostic information in post-STEMI patients.
- LA reservoir strain and conduit strain rate are significant predictors of MACEs and AF.
- Early STE evaluation enhances risk stratification and guides management for STEMI patients.
Keywords:
Left atrial deformationLow T3 syndromeST-segment elevation myocardial infarctionSpeckle-tracking echocardiographyMore Related Videos
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