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Related Experiment Video

Updated: Jan 4, 2026

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
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Diffusion Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3-K27M Mutation Using Apparent Diffusion

M S Aboian1, E Tong2, D A Solomon3

  • 1From the Department of Radiology and Biomedical Imaging (M.S.A.), Yale School of Medicine, New Haven, Connecticut mariam.aboian@yale.edu.

AJNR. American Journal of Neuroradiology
|November 8, 2019
PubMed
Summary
This summary is machine-generated.

Histone H3 K27M-mutant diffuse midline gliomas show no distinct diffusion characteristics compared to wild-type. However, lower apparent diffusion coefficient (ADC) values correlate with reduced survival rates in these aggressive pediatric brain tumors.

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Area of Science:

  • Neuro-oncology
  • Pediatric neurosurgery
  • Medical imaging

Background:

  • Diffuse midline gliomas with histone H3 K27M mutation are aggressive tumors with poor prognosis.
  • No qualitative imaging differences exist between H3 K27M-mutant and wild-type diffuse midline gliomas.
  • Diffusion-weighted imaging (DWI) utility for distinguishing these subtypes is evaluated.

Purpose of the Study:

  • To assess the effectiveness of diffusion-weighted imaging in differentiating histone H3 K27M-mutant from wild-type diffuse midline gliomas.
  • To explore the correlation between diffusion characteristics and patient survival.

Main Methods:

  • 31 pediatric patients with midline gliomas and histone H3 K27M mutation status assessed were included.
  • Apparent diffusion coefficient (ADC) was measured using a 3D whole-tumor method.
  • ADC histogram parameters were analyzed and compared between mutant and wild-type groups.

Main Results:

  • No statistically significant differences in ADC histogram parameters were observed between H3 K27M-mutant and wild-type tumors.
  • Subgroup analysis by tumor location did not reveal differences in ADC descriptive statistics.
  • Patients with shorter survival (<1 year) exhibited lower median ADC values compared to those surviving longer (>1 year).

Conclusions:

  • Diffusion characteristics do not reliably distinguish H3 K27M-mutant from wild-type diffuse midline gliomas.
  • Lower ADC values are associated with a poorer 1-year survival rate.
  • These findings offer insights into clinical course and outcomes for patients with diffuse midline gliomas.