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Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Related Experiment Video

Updated: Jan 4, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Sphingolipids in COPD.

Raja Chandra Chakinala1, Akshay Khatri2, Kriti Gupta3

  • 1Dept of Medicine, Westchester Medical Center, Valhalla, NY, USA rajachandra@gmail.com.

European Respiratory Review : an Official Journal of the European Respiratory Society
|November 8, 2019
PubMed
Summary

Sphingolipids, active lipid molecules, are increasingly recognized for their role in inflammation. This review focuses on their connection to lung inflammation in chronic obstructive pulmonary disease (COPD).

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Area of Science:

  • Lipid metabolism
  • Immunology
  • Pulmonary medicine

Background:

  • Sphingolipids are key cell membrane components with diverse biological roles.
  • Emerging evidence highlights sphingolipids as critical mediators of inflammation.
  • Inflammation is central to the pathogenesis of many lung diseases, including COPD.

Purpose of the Study:

  • To review the specific role of sphingolipids in lung inflammation within COPD.
  • To provide a clinically oriented synopsis of the sphingolipid-COPD inflammation link.

Main Methods:

  • Literature review focusing on sphingolipid metabolism and inflammatory pathways in COPD.
  • Synthesis of current research on sphingolipid involvement in COPD pathophysiology.

Main Results:

  • Sphingolipids actively participate in regulating inflammatory responses relevant to COPD.
  • Specific sphingolipid species and their metabolic pathways are implicated in COPD pathogenesis.

Conclusions:

  • Sphingolipids represent a significant, yet under-explored, area in COPD research.
  • Understanding sphingolipid roles may offer novel therapeutic targets for managing COPD-related lung inflammation.