Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A guest-host hydrogel for neural tissue engineering applications.

Journal of materials chemistry. B·2026
Same author

Cyclodextrin Nanoparticles and Injectable Polymer-Nanoparticle Hydrogels for Macrophage-Targeted Delivery of Small-Molecule Drugs.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Neoadjuvant atezolizumab + chemotherapy for resectable NSCLC: 3-year clinical update of phase II clinical trial results and translational findings.

Journal for immunotherapy of cancer·2024
Same author

Squeezable Hydrogel Microparticles for Single Extracellular Vesicle Protein Profiling.

Small (Weinheim an der Bergstrasse, Germany)·2024
Same author

Hydrogel-based approaches to target hypersensitivity mechanisms underlying autoimmune disease.

Advanced drug delivery reviews·2024
Same author

Tumor biomechanics as a novel imaging biomarker to assess response to immunotherapy in a murine glioma model.

Scientific reports·2024

Related Experiment Video

Updated: Jan 4, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.9K

Screening for new macrophage therapeutics.

Christopher B Rodell1, Peter D Koch1,2, Ralph Weissleder1,2

  • 1Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114.

Theranostics
|November 8, 2019
PubMed
Summary

Macrophages are key in human diseases and can be targeted therapeutically. Assessing their diverse phenotypes using in vitro and in vivo assays is crucial for developing advanced myeloid-targeted therapies.

Keywords:
macrophage therapeuticsscreening

More Related Videos

Production and Characterization of Human Macrophages from Pluripotent Stem Cells
08:05

Production and Characterization of Human Macrophages from Pluripotent Stem Cells

Published on: April 16, 2020

17.5K
A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
12:22

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

Published on: December 30, 2012

22.9K

Related Experiment Videos

Last Updated: Jan 4, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.9K
Production and Characterization of Human Macrophages from Pluripotent Stem Cells
08:05

Production and Characterization of Human Macrophages from Pluripotent Stem Cells

Published on: April 16, 2020

17.5K
A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
12:22

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

Published on: December 30, 2012

22.9K

Area of Science:

  • Immunology
  • Cell Biology
  • Pharmacology

Background:

  • Myeloid-derived macrophages are crucial in human diseases.
  • Their dynamic phenotypes and phagocytic nature make them ideal therapeutic targets.
  • Macrophage heterogeneity necessitates careful assessment for effective drug development.

Purpose of the Study:

  • To review current techniques for assessing macrophage phenotypes.
  • To highlight the importance of both in vitro and in vivo assays.
  • To discuss the future of noninvasive macrophage assessment in clinical practice.

Main Methods:

  • Review of state-of-the-art cell-based screening techniques.
  • Overview of in vivo imaging tools for macrophage phenotype assessment.
  • Discussion of combined in vitro and in vivo assay strategies.

Main Results:

  • Macrophages exhibit dynamic and heterogeneous phenotypes.
  • Pharmacological modulation of macrophages is a promising therapeutic strategy.
  • Current assays allow for detailed assessment of macrophage behavior.

Conclusions:

  • Developing next-generation therapeutics requires comprehensive macrophage phenotype screening.
  • Noninvasive assessment methods and laboratory assays are needed for clinical translation.
  • Myeloid-targeted therapeutics hold significant potential for treating various human diseases.