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Long non-coding RNAs associated with oral squamous cell carcinoma.
1Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. fenglu235@126.com.
European Review for Medical and Pharmacological Sciences
|November 8, 2019
Summary
Long non-coding RNAs (lncRNAs) show aberrant expression in oral squamous cell carcinoma (OSCC), influencing cellular processes. Further research into lncRNAs offers promise for novel biomarkers and therapeutic targets for this fatal head and neck cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Oral squamous cell carcinoma (OSCC) is a prevalent and deadly head and neck cancer.
- Understanding OSCC carcinogenesis and identifying effective biomarkers/therapeutics remain critical challenges.
Purpose of the Study:
- To review recent findings on long non-coding RNAs (lncRNAs) associated with OSCC.
- To explore the functional mechanisms and clinical relevance of these OSCC-related lncRNAs.
Main Methods:
- Literature review of recently published studies on OSCC and lncRNAs.
- Analysis of lncRNA expression patterns and their correlation with patient clinical status.
Main Results:
- lncRNAs are aberrantly expressed in various cancers, including OSCC.
- Emerging evidence links specific lncRNAs to OSCC development and progression.
Conclusions:
- lncRNAs represent a promising area for discovering novel OSCC biomarkers.
- Further investigation into lncRNA functions may yield new therapeutic strategies for oral cancer.
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