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Photoelectric-Responsive Extracellular Matrix for Bone Engineering.

Jieni Fu1, Xiangmei Liu1, Lei Tan1

  • 1Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering , Hubei University , Wuhan 430062 , People's Republic of China.

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|November 8, 2019
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Summary

This study demonstrates how a novel bismuth sulfide/hydroxyapatite film uses near-infrared light to control mesenchymal stem cell behavior, enhancing bone regeneration through precise optical stimulation.

Keywords:
Wnt/Ca2+ signaling pathwaybismuth sulfide/hydroxyapatitebone regenerationimplantsphotoelectrons

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cell Biology

Background:

  • Noninvasive optical stimulation offers precise control over cellular activities.
  • Bone regeneration can be improved by orchestrating cell fate and behavior.

Purpose of the Study:

  • To develop a photoelectric-responsive microenvironment for controlling cell fate and enhancing bone regeneration.
  • To investigate the mechanism of optical stimulation on mesenchymal stem cells (MSCs) for therapeutic applications.

Main Methods:

  • Fabrication of a bismuth sulfide/hydroxyapatite (BS/HAp) film for a photoelectric-responsive microenvironment.
  • Application of near-infrared (NIR) light to induce photocurrent and modulate MSC behavior.
  • Analysis of cellular responses including ion flux, gene expression (RNA sequencing), and signaling pathways (Wnt/Ca2+).

Main Results:

  • BS/HAp film exhibited an increased photocurrent under NIR light due to hole depletion and interfacial charge transfer.
  • Photoelectrons activated Na+ channels in MSCs, altering cell adhesion and membrane potential.
  • NIR light stimulation led to Ca2+ flux, upregulation of FDE1, and activation of TCF/LEF transcription via the Wnt/Ca2+ pathway, promoting osteogenic differentiation.

Conclusions:

  • A novel strategy for remotely and noninvasively controlling cell differentiation using NIR light and a photoelectric microenvironment was established.
  • This approach holds potential for advanced biological therapies in bone regeneration and other regenerative medicine applications.