Related Experiment Video

Updated: Jan 4, 2026

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.6K

Current progress and future perspectives of polypharmacology : From the view of non-small cell lung cancer

Ramanathan Karuppasamy1, Shanthi Veerappapillai1, Sayoni Maiti1

  • 1Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.

Seminars in Cancer Biology
|November 8, 2019
PubMed

Insights

Drug repositioning offers a promising strategy to find new treatments for non-small cell lung cancer (NSCLC). This approach aims to overcome drug resistance and improve survival rates for this deadly disease.

Area of Science:

  • Oncology
  • Pharmacology
  • Systems Biology

Background:

  • Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality globally.
  • Current treatments for NSCLC, especially metastatic disease, have limited efficacy and survival rates remain poor.
  • Acquired resistance to conventional chemotherapy further complicates NSCLC treatment.

Purpose of the Study:

  • To review innovative drug repurposing strategies for NSCLC therapeutics.
  • To highlight successful examples of drug repurposing in NSCLC treatment.
  • To emphasize the potential of repurposed drugs in combination therapies to overcome resistance.

Main Methods:

  • Literature review of drug repurposing approaches in cancer therapy.
  • Analysis of systems biology-driven strategies for identifying novel drug actions.
  • Examination of clinical successes and potential of repurposed drugs for NSCLC.

Main Results:

  • Drug repurposing presents an affordable and efficient method for discovering new therapeutic applications.
  • Several repurposed drugs have shown promise in preclinical and clinical studies for NSCLC.
  • Combination therapies involving repurposed drugs may enhance efficacy against resistant NSCLC.

Conclusions:

  • Drug repurposing is a valuable strategy to accelerate the development of next-generation NSCLC therapeutics.
  • Repurposed drugs, when combined with existing agents, can significantly strengthen the therapeutic arsenal against NSCLC.
  • This approach holds promise for improving clinical outcomes and combating drug resistance in NSCLC patients.
Keywords:
Drug DiscoveryDrug repurposingDrug resistanceLung cancerRepositioned hits

More Related Videos

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

297
Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

4.5K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Nonlinear Pharmacokinetics: Overview01:19

Nonlinear Pharmacokinetics: Overview

Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
1000
Nonlinear Pharmacokinetics: Role of Transporters01:27

Nonlinear Pharmacokinetics: Role of Transporters

A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
240
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K