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SGLT1 inhibition boon or bane for diabetes-associated cardiomyopathy

Jaspreet Kalra1, Suresh Babu Mangali1, Deepika Dasari1

  • 1Department of Pharmacy, Birla Institute of Technology and Sciences (BITS) Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet, Hyderabad,, Andhra Pradesh, 500078, India.

Fundamental & Clinical Pharmacology
|November 8, 2019
PubMed

Insights

Sodium glucose transporter (SGLT) inhibitors show promise for treating cardiac complications in diabetes. These agents effectively manage hyperglycemia and associated heart problems by targeting metabolic shifts.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Chronic hyperglycemia in diabetes mellitus (DM) leads to glucotoxicity, causing vascular and metabolic alterations.
  • Cardiac abnormalities are prevalent in over half of individuals with diabetes, contributing significantly to mortality.
  • Standard glucose-lowering treatments show limited impact on cardiovascular disease (CVD) risk in type 2 diabetes (T2D).

Purpose of the Study:

  • To review the therapeutic potential of sodium glucose transporter (SGLT) inhibitors for diabetes-related cardiac complications.
  • To highlight the role of SGLT inhibitors in addressing cardiac energy substrate metabolism deregulation.

Main Methods:

  • Review of in vitro and in vivo studies on SGLT inhibitors.
  • Analysis of clinical trial data on SGLT inhibitor efficacy.
  • Examination of SGLT inhibitors' impact on cardiac metabolism.

Main Results:

  • SGLT inhibitors demonstrate efficacy as antidiabetic agents with antihyperglycemic activity.
  • These inhibitors show potential in treating cardiac abnormalities associated with diabetes.
  • SGLT inhibitors may correct deregulation of cardiac energy substrate metabolism.

Conclusions:

  • SGLT inhibitors represent a promising therapeutic strategy for managing cardiac complications in diabetes.
  • Their dual action on hyperglycemia and cardiac metabolism offers a novel approach to T2D cardiovascular risk.
  • Further research supports SGLT inhibitors as successful drug candidates for diabetes-related cardiac perturbations.
Keywords:
diabetes mellitusdiabetic cardiomyopathysodium glucose cotransporter (SGLT)

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