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Regulation of Cell Behavior by Hydrostatic Pressure
Shaobao Liu1, Ru Tao2, Ming Wang2
1State Key Laboratory of Mechanics andControl of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
Applied Mechanics Reviews
|November 9, 2019
Summary
Hydrostatic pressure (HP) influences cell functions like differentiation and migration. Understanding HP
Area of Science:
- Biomedical Engineering
- Cell Biology
- Physiology
Background:
- Hydrostatic pressure (HP) is a critical biophysical regulator of cellular functions.
- Aberrant HP levels are implicated in various diseases, such as glaucoma and cardiovascular remodeling.
Purpose of the Study:
- To review recent advancements in quantifying and predicting cellular responses to HP.
- To explore HP's role across diverse tissue systems.
Main Methods:
- Literature review of studies on cellular responses to hydrostatic pressure.
- Synthesis of findings across brain, eye, vasculature, bladder, and cartilage tissues.
Main Results:
- Detailed presentation of how cells in various tissues respond to hydrostatic pressure.
- Identification of common and tissue-specific cellular behaviors regulated by HP.
Conclusions:
- Hydrostatic pressure significantly impacts cell behavior and tissue homeostasis.
- Further research into HP's role offers potential therapeutic strategies for related pathologies.
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