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Single Cell Durotaxis Assay for Assessing Mechanical Control of Cellular Movement and Related Signaling Events
Published on: August 27, 2019
Regulation of Cell Behavior by Hydrostatic Pressure
Shaobao Liu1, Ru Tao2, Ming Wang2
1State Key Laboratory of Mechanics andControl of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
Abstract:
Hydrostatic pressure (HP) regulates diverse cell behaviors including differentiation, migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies including glaucoma and hypertensive fibrotic remodeling. In this review, recent advances in quantifying and predicting how cells respond to HP across several tissue systems are presented, including tissues of the brain, eye, vasculature and bladder, as well as articular cartilage. Finally, some promising directions on the study of cell behaviors regulated by HP are proposed.
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