Related Experiment Video

Updated: Jan 4, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.8K

Contrast-Induced Acute Kidney Injury: Review and Practical Update

Ramez Morcos1, Michael Kucharik2, Pirya Bansal3

  • 1Department of Internal Medicine, Florida Atlantic University, Boca Raton, FL, USA.

Clinical Medicine Insights. Cardiology
|November 9, 2019
PubMed

Insights

Contrast-induced acute kidney injury (CI-AKI) is a risk during cardiac procedures. Prevention focuses on limiting contrast dye and ensuring hydration, though further research is needed for effective prophylactic treatments.

Area of Science:

  • Nephrology
  • Cardiology
  • Interventional Radiology

Background:

  • Contrast-induced acute kidney injury (CI-AKI) is a significant complication following cardiac catheterization.
  • Patient safety and reducing procedural morbidity are key concerns in interventional cardiology.
  • Understanding CI-AKI is crucial for optimizing patient care and outcomes.

Purpose of the Study:

  • To review the pathophysiology, predictors, and clinical management of CI-AKI.
  • To explore a potential association between CI-AKI and left atrial appendage closure procedures.
  • To summarize current preventive strategies and the status of adjunctive therapies.

Main Methods:

  • Literature review focusing on CI-AKI pathophysiology and management.
  • Analysis of risk factors and preventive measures for CI-AKI.
  • Discussion of emerging therapeutic options and their evidence base.

Main Results:

  • Key preventive strategies include minimizing contrast media volume and maintaining adequate intravenous hydration.
  • Left atrial appendage closure is suggested as a potential area for CI-AKI association.
  • Several adjunctive pharmacotherapies show promise but lack consensus for prophylactic use.

Conclusions:

  • Minimizing contrast exposure and hydration are primary CI-AKI prevention methods.
  • Further investigation is warranted for the role of left atrial appendage closure in CI-AKI.
  • Established prophylactic pharmacotherapies for CI-AKI are currently lacking consensus recommendations.

Keywords:
Contrast-induced acute kidney injurycardiac catheterizationclinical managementpathophysiologypredictors

More Related Videos

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

2.3K
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.2K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
231
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
484
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
253
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
810
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
340
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
742