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The relation between serum phosphorus levels and long-term mortality in Chinese patients with ST-segment elevation
Guo-Hua Zhu1, Xi-Peng Sun1, Zhi Liu1
1Department of Cardiology, Xuanwu Hospital Capital Medical University, Beijing, China.
Insights
Elevated serum phosphorus levels increase mortality risk in Chinese patients with ST-segment elevation myocardial infarction (STEMI) and preserved kidney function. Lower phosphorus levels (2.51-3.50 mg/dL) were associated with the lowest mortality rates.
Area of Science:
- Cardiology
- Clinical Biochemistry
- Public Health
Background:
- Elevated serum phosphorus is linked to adverse cardiovascular outcomes.
- This study focuses on Chinese patients with ST-segment elevation myocardial infarction (STEMI) and preserved renal function.
- Investigating the impact of serum phosphorus on mortality in this specific population is crucial.
Purpose of the Study:
- To examine the association between serum phosphorus levels and all-cause mortality.
- To determine if baseline serum phosphorus levels predict mortality in STEMI patients with normal kidney function.
- To identify optimal serum phosphorus ranges for better outcomes in STEMI patients.
Main Methods:
- A cohort of 1989 STEMI patients with preserved renal function was analyzed.
- Patients were stratified into four groups based on baseline serum phosphorus levels.
- Cox proportional-hazards models were used to assess mortality risk, adjusting for confounders.
Main Results:
- A total of 211 deaths (10.6%) occurred during a median follow-up of 54.6 months.
- The lowest mortality was observed in patients with serum phosphorus levels of 2.51-3.50 mg/dL.
- Higher serum phosphorus levels (>3.50 mg/dL) and very low levels (<2.50 mg/dL) were associated with increased all-cause mortality.
Conclusions:
- Elevated serum phosphorus levels are significantly associated with increased all-cause mortality in STEMI patients with preserved renal function.
- Maintaining serum phosphorus within a specific range (2.51-3.50 mg/dL) may be beneficial for STEMI patients.
- These findings highlight the importance of monitoring and managing serum phosphorus in cardiovascular disease management.
Background:
Elevated serum phosphorus levels may be associated with adverse outcomes in cardiovascular disease. This study aimed to investigate the relation between serum phosphorus levels and risk of all-cause mortality in Chinese patients with ST-segment elevation myocardial infarction (STEMI) who had preserved renal function at baseline.
Methods:
We enrolled patients with STEMI who had preserved renal function at baseline in Xuanwu Hospital from January 2011 to December 2016. Those patients were divided into four groups based on serum phosphorus levels. All-cause mortality rates were compared between groups. Mean duration of follow up was 54.6 months. We used Cox proportional-hazards models to examine the relation between serum phosphorus levels and all-cause mortality after adjustment for potential confounders.
Results:
1989 patients were involved and 211 patients (10.6%) died during follow-up. Based on serum phosphorus levels, patients were categorized into the following groups: < 2.50 mg/dL (n = 89), 2.51-3.50 mg/dL (n = 1066), 3.51-4.50 mg/dL (n = 672) and > 4.50 mg/dL (n = 162), respectively. The lowest mortality occurred in patients with serum phosphorus levels between 2.51-3.50 mg/dL, with a multivariable-adjusted hazard ratio of 1.19 (95% CI: 0.64-1.54), 1.37 (95% CI: 1.22-1.74), and 1.46 (95% CI: 1.35-1.83) in patients with serum phosphorus levels of < 2.50 mg/dL, 3.51-4.50 mg/dL and > 4.50 mg/dL, respectively.
Conclusions:
Elevated serum phosphorus levels were associated with all-cause mortality in Chinese patients with STEMI who had preserved renal function at baseline.
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