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Influencing factors of vascular endothelial function in patients with non-obstructive coronary atherosclerosis: a

Yin-Ping Li1, Zhen-Xing Fan2, Jing Gao2

  • 1Department of Nephrology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, 100053, China.

BMC Cardiovascular Disorders
|February 1, 2020
PubMed

Insights

Endothelial dysfunction is common in non-obstructive coronary artery atherosclerosis. Improving endothelial progenitor cells (EPCs) and lowering serum creatinine can enhance vascular endothelial function in these patients.

Area of Science:

  • Cardiovascular Research
  • Vascular Biology
  • Medical Science

Background:

  • Endothelial dysfunction is a significant factor in non-obstructive coronary artery atherosclerosis.
  • This study investigates vascular endothelial function and its determinants in affected patients.

Purpose of the Study:

  • To evaluate vascular endothelial function in patients with non-obstructive coronary artery atherosclerosis.
  • To identify factors influencing endothelial function and its improvement.

Main Methods:

  • 131 patients with non-obstructive coronary artery atherosclerosis were enrolled.
  • Flow-mediated dilatation (FMD) was measured at baseline and 1-year follow-up.
  • Endothelial progenitor cells (EPCs) were quantified using flow cytometry.

Main Results:

  • Lower baseline FMD was associated with higher systolic blood pressure, pulse pressure, and HbA1c.
  • Baseline FMD showed a negative correlation with EPC counts and systolic blood pressure.
  • A significant increase in FMD was observed at 1-year follow-up, with elevated EPC counts and decreased serum creatinine predicting improvement.

Conclusions:

  • Hypertension and elevated HbA1c are risk factors for endothelial dysfunction in this patient group.
  • Increased EPC counts and reduced serum creatinine levels are key predictors of improved endothelial function.
Abstract

Keywords:
Endothelial dysfunctionEndothelial progenitor cellsFlow-mediated dilatationNon-obstructive coronary atherosclerosis

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