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Epidermolytic Acanthoma Mimicking Condyloma: A Case Report
Amandine Dupont1, Hélène Marescassier2, Gürkan Kaya1,2
1Department of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.
Dermatopathology (Basel, Switzerland)
|November 9, 2019
Summary
Epidermolytic acanthoma, a rare benign skin tumor, can be misdiagnosed due to its misleading appearance. This case highlights the diagnostic challenges, emphasizing the need for accurate identification of this genital lesion.
Area of Science:
- Dermatology
- Pathology
Background:
- Epidermolytic acanthoma is a rare benign neoplasm.
- It typically presents as papules on the trunk, extremities, or genitalia.
- Lesions are usually asymptomatic but can be pruritic.
Observation:
- The clinical presentation of epidermolytic acanthoma is often misleading.
- It is frequently misdiagnosed histologically.
- It is often confused with condyloma acuminatum.
Findings:
- This report details a case of epidermolytic acanthoma on the penis of a 57-year-old male.
- The final diagnosis was established after several years of diagnostic uncertainty.
- The case underscores the challenges in differentiating this benign tumor from other genital lesions.
Implications:
- Accurate diagnosis of epidermolytic acanthoma is crucial to avoid misdiagnosis and inappropriate treatment.
- Increased awareness among clinicians can improve diagnostic accuracy for this rare condition.
- Further research may elucidate specific diagnostic markers for epidermolytic acanthoma.

