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Updated: Jan 4, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Asymmetric Hydroboration of Heteroaryl Ketones by Aluminum Catalysis
Yury Lebedev1,2, Iuliia Polishchuk1,2, Bholanath Maity1
1King Abdullah University of Science and Technology (KAUST) KAUST Catalysis Center (KCC) , Thuwal 23955-6900 , Saudi Arabia.
Abstract:
A series of methyl aluminum complexes bearing chiral biphenol-type ligands were found to be highly active catalysts in the asymmetric reduction of heterocyclic ketones (S/C = 100-500, ee up to 99%). The protocol is suitable for a wide range of substrates and has a high tolerance to functional groups. The formed 2-heterocyclic-alcohols are valuable building blocks in drug discovery or can be used as ligands in asymmetric catalysis. Isolation and comprehensive characterization of the reaction intermediates support a catalysis cycle proposed by DFT calculations.
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