Related Experiment Video
Updated: Jan 4, 2026
Formulation of Zinc-Based Nanomaterials using the Eucommia ulmoides Bark Extract and their Wound Healing Potential
Published on: December 27, 2024
[Histological evaluation of inflammatory response to zinc-oxide-eugenol filling materials in a soft and bone tissues]
S V Tarasenko1, L A Grigor'janc2, E A Morozova1
1First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.
Aim:
To evaluate and to compare the intensity of the inflammatory response to zinc-oxide-eugenol based filling material in rabbit's soft and bone tissue.
Material And Methods:
The study employed 20 chinchilla rabbits. The artificial defects were formed in jaw and in soft tissues and filled by zinc-oxide-eugenol based filling material. After 14 or 30 days the animals were euthanized, and tissue samples were analyzed with microscope.
Results:
Histological analysis revealed that zinc-oxide-eugenol based filling material support inflammation reaction in the tissue, but bone tissue showed statistically lower inflammatory response in comparison to soft tissue (p<0,05).
Conclusion:
Extrusion of zinc-oxide-eugenol based filling material from root canal is undesirable as it leads to complex unfavorable tissue reaction for its elimination, more pronounced in soft tissues.
