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Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus
Shuai-Cheng Wu1,2, Fei Liu1, Kui Zhu1
1Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine , China Agricultural University , No. 2 Yuanmingyuan West Road , Beijing 100193 , People's Republic of China.
Journal of Agricultural and Food Chemistry
|November 9, 2019
Summary
Natural products from plants and microbes offer a promising antivirulence strategy against antibiotic-resistant Staphylococcus aureus (S. aureus) infections. These compounds target S. aureus virulence factors, aiding existing antibiotics and combating drug resistance.
Area of Science:
- Microbiology and Infectious Diseases
- Natural Product Chemistry
- Pharmacology
Background:
- Rising incidence of antibiotic-resistant Staphylococcus aureus (S. aureus) infections demands novel therapeutic approaches.
- Antivirulence strategies present a low-resistance selective pressure alternative to traditional antibiotics.
- Plants and microorganisms are rich sources of natural products with antibacterial potential.
Purpose of the Study:
- To review the mechanisms of major S. aureus virulence factors.
- To provide an overview of natural products targeting S. aureus virulence.
- To discuss the potential of natural products as adjuvant therapy against antibiotic-resistant S. aureus.
Main Methods:
- Literature review of S. aureus virulence mechanisms (agr quorum-sensing, biofilm, alpha-hemolysin, sortase A, staphyloxanthin).
- Survey of natural products from plants and microorganisms with anti-virulence activity.
- Analysis of adjuvant effects of natural products with existing antibiotics.
Main Results:
- Identified key virulence factors of S. aureus and their roles in infection.
- Cataloged various plant and microbial natural products demonstrating activity against S. aureus virulence.
- Highlighted the synergistic effects of these natural products with conventional antibiotics.
Conclusions:
- Natural products offer a viable antivirulence approach to combat antibiotic-resistant S. aureus.
- These compounds can enhance the efficacy of existing antibiotics.
- Further research into limitations and solutions is crucial for developing new antibacterial drugs.
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