Propeller echo-planar time-resolved imaging with dynamic encoding (PEPTIDE)

To develop a motion-robust extension to the recently developed echo-planar time-resolved imaging (EPTI) approach, referred to as PROPELLER EPTI with dynamic encoding (PEPTIDE), by incorporating rotations into the rapid, multishot acquisition to enable shot-to-shot motion correction.

Echo-planar time-resolved imaging is a multishot EPI-based approach that allows extremely rapid acquisition of distortion-free and blurring-free multicontrast imaging and quantitative mapping. By combining k-space encoding rotations into the EPTI sampling strategy to repeatedly sample the low-resolution k-space center, PEPTIDE enables significant tolerance to shot-to-shot motion and B₀ phase variations. Retrospective PEPTIDE data sets are created through a combination of in vivo EPTI data sets with rotationally acquired protocols, to enable direct comparison of the 2 methods and their robustness to identical motion. The PEPTIDE data sets are also prospectively acquired and again compared with EPTI, in the presence of true subject motion.

The PEPTIDE approach is shown to be motion-robust to even severe subject motion (demonstrated > 30° in-plane rotation, alongside translational and through-plane motion), while maintaining the rapid encoding benefits of the EPTI technique. The technique enables accurate quantitative maps to be calculated from even severe motion data sets. While the performance of the motion correction depends on the type and severity of motion encountered, in all cases PEPTIDE significantly increases image quality in the presence of motion comparative to conventional EPTI.

The newly developed PEPTIDE technique combines a high degree of motion tolerance into the EPTI framework, enabling highly rapid acquisition of distortion-free and blurring-free images at multiple TEs in the presence of motion.