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Related Experiment Videos

ANRIL and atherosclerosis.

Li Chen1, Hua Qu2, Ming Guo3

  • 1Peking University Traditional Chinese Medicine Clinical Medical School (Xi yuan), Beijing, China.

Journal of Clinical Pharmacy and Therapeutics
|November 9, 2019
PubMed
Summary
This summary is machine-generated.

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Antisense non-coding RNA at the INK4 locus (ANRIL) is implicated in atherosclerosis and coronary heart disease (CHD) development. Targeting ANRIL may offer a novel therapeutic strategy for atherosclerotic diseases.

Area of Science:

  • Molecular biology
  • Genetics
  • Cardiovascular research

Background:

  • Antisense non-coding RNA at the INK4 locus (ANRIL) is a 3.8-kb non-coding RNA transcribed from human chromosome 9.
  • ANRIL is associated with vascular endothelium dysfunction, vascular smooth muscle cell (VSMC) alterations, and metabolic disorders.
  • Genome-wide association studies link ANRIL to coronary heart disease (CHD) and identify it as a potential biomarker.

Purpose of the Study:

  • To review the pathological mechanisms of ANRIL in atherosclerotic development.
  • To discuss the significance of ANRIL as a predictor of cardiovascular disease.
  • To explore ANRIL's role in atherogenesis.

Main Methods:

  • Literature review of PubMed, EMBASE, and Cochrane databases.
Keywords:
ANRILatherosclerosisbiomarkermechanism

Related Experiment Videos

  • Analysis of articles focusing on ANRIL's role in atherosclerotic disease development.

    • Main Results:

    • Abnormal ANRIL expression is linked to vascular endothelium injury, VSMC dysfunction, mononuclear cell adhesion, and glycolipid metabolism disorder.
    • ANRIL influences DNA damage and competes with endogenous RNAs.
    • ANRIL regulates single nucleotide polymorphisms (SNPs) to accelerate CHD progression.

    Conclusions:

    • ANRIL plays a critical role in accelerating atherosclerosis (AS) development.
    • ANRIL is a significant risk factor for coronary heart disease (CHD).
    • Developing ANRIL-based therapies for AS in CHD warrants further investigation.