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Updated: Jul 4, 2026
06:38
The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
Published on: December 19, 2025
Thermochemical Micro-Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal
Summary
A novel micro-explosive thermochemical thrombolysis (METCT) therapy using liquid alkali metal (LAM@oil) safely and rapidly dissolves blood clots. This efficient treatment offers a promising alternative to current thrombolytic drugs.
Area of Science:
- Biomedical Engineering
- Materials Science
- Cardiovascular Research
Background:
- Thrombotic vascular diseases cause significant mortality globally.
- Current therapies for blood clots have limitations like bleeding risks and low efficiency.
Purpose of the Study:
- To develop a novel, rapid, and safe method for dissolving blood clots.
- To evaluate the efficacy and safety of micro-explosive thermochemical thrombolysis (METCT).
Main Methods:
- Developed a liquid alkali metal (LAM) encapsulated in dimethyl silicone (LAM@oil) system.
- Administered LAM@oil via proximal injection for vascular recanalization.
- Investigated the synergistic triple-action mechanism: mechanical, alkaline, and thermal thrombolysis.
Main Results:
- Achieved prompt vascular recanalization in under 90 seconds.
- Demonstrated significantly higher thrombolytic efficacy (10.87% residual thrombus) compared to urokinase (80.86%).
- Confirmed non-toxic, biocompatible byproducts with no associated bleeding risks.
Conclusions:
- METCT using LAM@oil is a highly effective and safe alternative to conventional thrombolytics.
- This technology shows great potential for clinical translation in managing acute thrombosis.
- Offers a cost-effective and byproduct-green approach for blood clot dissolution.
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