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Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges

Zeenat Mirza1, Sajjad Karim2

  • 1King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Lab Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Seminars in Cancer Biology
|November 10, 2019
PubMed

Insights

Nanoparticles offer a promising solution for breast cancer (BC) gene therapy, overcoming limitations of conventional treatments. These nanocarriers enhance drug delivery, improving bioavailability and targeting specific BC genes for better therapeutic outcomes.

Area of Science:

  • Oncology
  • Nanomedicine
  • Gene Therapy

Background:

  • Breast cancer (BC) remains a leading cause of female mortality, with conventional treatments facing challenges like low bioavailability, poor cellular uptake, resistance, and toxicity.
  • Gene therapy for BC using free nucleic acids is hindered by poor cell uptake and instability.
  • Nanomedicine offers a promising avenue to overcome these limitations through targeted drug and gene delivery.

Purpose of the Study:

  • To review the mechanisms of nanoparticle-mediated targeted drug delivery for breast cancer.
  • To discuss recent advancements in nanoparticle-based therapeutic strategies for BC gene therapy, including small interfering RNA (siRNA), microRNA (miRNA), and gene augmentation.
  • To explore the future prospects and challenges of nanoparticle-based therapies in breast cancer treatment.

Main Methods:

  • Review of nanoparticle-based drug delivery mechanisms.
  • Analysis of recent advancements in nanoparticle carriers for gene regulatory agents (siRNA, miRNA) and gene augmentation.
  • Discussion of therapeutic strategies and clinical implications.

Main Results:

  • Nanoparticles can significantly improve circulation time, bioavailability, and targeted delivery of therapeutic agents for BC.
  • Nanocarriers enhance cellular uptake and reduce immune recognition, crucial for effective gene therapy.
  • Nanoparticle-based strategies show potential in overcoming resistance and reducing toxicity associated with conventional BC treatments.

Conclusions:

  • Nanoparticle-based gene therapy represents a significant advancement in overcoming the limitations of traditional breast cancer treatments.
  • Further research and development in nanoparticle design and application are crucial for realizing the full therapeutic potential in BC.
  • Nanomedicine holds promise for more effective and safer breast cancer treatment strategies through targeted gene delivery.
Keywords:
Breast cancerDrug deliveryGene therapyNanoparticlesTNBC

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