Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PROQURE-I: a phase I study adding concurrent [<sup>177</sup>Lu]Lu-PSMA-617 to EBRT and ADT in curative intent treatment of N1 prostate cancer.

European journal of nuclear medicine and molecular imaging·2026
Same author

Structural determinants of beta-cell failure in type 2 diabetes: a multimodality imaging study.

Metabolism: clinical and experimental·2026
Same author

Pyomyositis, a rare complication of a urinary tract infection on FDG PET/CT.

European journal of nuclear medicine and molecular imaging·2026
Same author

Smart scanning for two: [<sup>18</sup>F]FDG dose optimization for pregnant patients using LAFOV PET/CT technology.

EJNMMI physics·2026
Same author

Actionable Feedback on Signal-to-Background Ratios During Drop-in Radioguided Surgery.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Toward Reliable Lesion Labeling Standards for AI in Nuclear Medicine.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026

Related Experiment Video

Updated: Jan 4, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.5K

Multicentre quantitative 68Ga PET/CT performance harmonisation.

Daphne M V Huizing1, Daniëlle Koopman2, Jorn A van Dalen3

  • 1Department of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, The Netherlands.

EJNMMI Physics
|November 10, 2019
PubMed
Summary

Multicenter 68Gallium-PET/CT quantification shows variability, performing near the lower limits of 18Fluorine standards. Correcting for cross-calibration differences is recommended to improve comparability in multicenter studies.

Keywords:
68Gallium PET/CTHarmonisationImage qualityQuantification

More Related Videos

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

812
Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
06:53

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

6.0K

Related Experiment Videos

Last Updated: Jan 4, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.5K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

812
Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
06:53

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

6.0K

Area of Science:

  • Nuclear Medicine
  • Radiochemistry
  • Medical Imaging

Background:

  • Quantitative Positron Emission Tomography (PET)/CT requires standardized performance metrics for multicenter studies.
  • The EANM Research Ltd. (EARL) provides standards for 18F-FDG PET/CT but not for 68Ga PET/CT.

Purpose of the Study:

  • To evaluate the variability of quantitative 68Gallium-PET/CT (68Ga PET/CT) in a multicenter setting.
  • To assess the feasibility of establishing standardized quantification protocols for 68Ga PET/CT.

Main Methods:

  • A survey of clinical 68Ga PET/CT protocols was conducted across Dutch hospitals.
  • Phantom studies using both 68Ga and 18F were performed by 8 centers on 13 PET/CT systems.
  • Image noise, recovery coefficients (RCs), and cross-calibration between PET/CT systems and dose calibrators were evaluated.

Main Results:

  • Significant variations in clinical 68Ga PET/CT acquisition and reconstruction protocols were observed.
  • 68Ga PET/CT image noise was consistently below 10%.
  • Cross-calibration showed within 10% deviation, though some systems overestimated 18F or underestimated 68Ga activity concentration. RC curves for 68Ga were at the lower limit of EARL standards. After cross-calibration correction, 68Ga performance was 5% below EARL specifications.

Conclusions:

  • 68Ga PET/CT quantification currently operates at the lower bounds of established EARL standards for 18F.
  • Correction for local 68Ga/18F cross-calibration is crucial for accurate multicenter quantification.
  • Maintaining a single EARL reconstruction protocol is advised to avoid protocol proliferation and ensure comparability.