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Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
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Skeletal muscle adiponectin induction in obesity and exercise
Sergio F Martinez-Huenchullan1, Charmaine S Tam2, Linda A Ban3
1Greg Brown Diabetes & Endocrinology Laboratory, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; School of Physical Therapy, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.
Metabolism: Clinical and Experimental
|November 11, 2019
Summary
Obesity impairs skeletal muscle function, but exercise may help. This review explores how obesity affects muscle adiponectin and how exercise can reverse these detrimental metabolic changes.
Area of Science:
- Metabolic function
- Skeletal muscle physiology
- Exercise science
Background:
- Obesity negatively impacts skeletal muscle metabolic health.
- Adiponectin, an insulin-sensitizing myokine, plays a protective role against metabolic insults.
- Sustained metabolic stress, like high-fat diets, dysregulates adiponectin, leading to muscle impairment.
Purpose of the Study:
- To review the impact of obesity on skeletal muscle adiponectin.
- To discuss how exercise interventions may influence this response in obesity.
Main Methods:
- Literature review of studies on obesity, skeletal muscle, and adiponectin.
- Analysis of existing research on exercise's effects on muscle adiponectin in obese contexts.
Main Results:
- Obesity disrupts normal adiponectin induction in skeletal muscle.
- Exercise interventions show potential to prevent or reverse obesity-induced muscle metabolic dysfunction.
Conclusions:
- Skeletal muscle adiponectin regulation is altered in obesity.
- Exercise may be a viable strategy to restore metabolic health in skeletal muscle affected by obesity.
