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Sleep modulates effective connectivity: A study using intracranial stimulation and recording.

Anca Adriana Arbune1, Irina Popa1, Ioana Mindruta2

  • 1Department of Neurology, University Emergency Hospital, Bucharest, Romania; Department of Clinical Neurosciences, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|November 12, 2019
PubMed
Summary

Sleep alters brain network organization, impacting excitability differently in healthy versus epileptic brain regions. These sleep-related network changes in epilepsy patients may affect cognitive functions.

Keywords:
Effective connectivityEpilepsySingle pulse electrical stimulationSleepstereo-EEG

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Area of Science:

  • Neuroscience
  • Epileptology
  • Sleep Science

Background:

  • Sleep is crucial for memory and cognitive function.
  • Epilepsy is often associated with disrupted sleep architecture and cognitive deficits.
  • Understanding sleep's impact on brain networks is vital for epilepsy management.

Purpose of the Study:

  • To investigate how sleep affects the organization of cortical networks.
  • To examine differences in network modulation by sleep in epileptic versus non-epileptic brain tissue.

Main Methods:

  • Cortico-cortical evoked responses were analyzed using single pulse electrical stimulation (SPES) in 25 epilepsy patients.
  • Data were collected during wakefulness and NREM stage 2 sleep using stereo-EEG.
  • Graph theory analysis was applied to assess effective connectivity.

Main Results:

  • Sleep increased overall brain excitability, irrespective of epileptogenicity.
  • Sleep differentially modulated local and distant connections based on tissue epileptogenicity.
  • In non-epileptogenic areas, frontal lobe connectivity strengthened during sleep, with altered hippocampal and temporal neocortex connections.

Conclusions:

  • Sleep actively reconfigures functional brain networks.
  • The impact of sleep on network organization is dependent on the underlying tissue epileptogenicity.
  • Observed network changes during sleep have potential implications for cognitive function in epilepsy.