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Sclerosing Mesenteritis Mimicking IgG4-related Disease
Masahide Fukuda1,2, Toru Miyake3, Akiko Matsubara1
1Division of Diagnostic Pathology, Department of Clinical Laboratory Medicine, Shiga University of Medical Science Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|November 12, 2019
Summary
A rare case of sclerosing mesenteritis was diagnosed in a patient previously treated for adrenal small cell carcinoma. Histological analysis revealed similarities to IgG4-related disease in both lesions.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- A 72-year-old male patient with a history of left adrenal small cell carcinoma underwent long-term follow-up.
- The patient had undergone surgery for the initial adrenal malignancy.
Observation:
- Follow-up computed tomography revealed a 6-cm mesenteric mass.
- Surgical exploration and histological examination diagnosed the mass as sclerosing mesenteritis.
Findings:
- Re-examination of the original adrenal tumor specimens showed panniculitis.
- Both the mesenteric mass and the adrenal tumor exhibited histological features suggestive of IgG4-related disease (RD).
- However, the findings did not fully meet the established clinical or histological criteria for IgG4-RD.
Implications:
- This case highlights a potential association between sclerosing mesenteritis and IgG4-related disease in patients with a history of adrenal small cell carcinoma.
- Further research may clarify the relationship and diagnostic challenges in such complex cases.
- The findings underscore the importance of thorough histopathological review for rare conditions.
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