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G Protein-Coupled Estrogen Receptor: A Potential Therapeutic Target in Cancer

Shen Xu1, Shan Yu2,3, Daming Dong1

  • 1Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Frontiers in Endocrinology
|November 12, 2019
PubMed

Insights

The G protein-coupled estrogen receptor (GPER) regulates cell functions and is linked to cancer progression. Understanding GPER in malignancies may reveal new therapeutic targets for estrogen-related cancers.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • The G protein-coupled estrogen receptor (GPER) is a key mediator of non-genomic estrogen signaling.
  • GPER activation influences cell growth, migration, and apoptosis across various tissues.
  • A strong association exists between GPER and the progression of numerous cancers.

Purpose of the Study:

  • To review the cell signaling pathways regulated by GPER.
  • To detail the specific functions of GPER in the context of cancer biology.
  • To explore the potential of GPER as a therapeutic target in malignancies.

Main Methods:

  • Literature review of GPER signaling.
  • Analysis of GPER's role in different cancer types.
  • Synthesis of current research on GPER and cancer.

Main Results:

  • GPER mediates diverse cellular responses through multiple downstream pathways.
  • GPER's involvement in cancer progression is increasingly recognized.
  • Estrogen-related cancers show a significant correlation with GPER.

Conclusions:

  • GPER plays a critical role in regulating cellular processes relevant to cancer.
  • Targeting GPER may offer novel therapeutic strategies for cancer treatment.
  • Further research into GPER functions can identify new avenues for oncology drug development.
Keywords:
G protein-coupled estrogen receptorcancerestrogennon-genomic estrogen pathwayssignaling pathway

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