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Updated: Jan 4, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Prospects for the involvement of cancer stem cells in the pathogenesis of osteosarcoma
Sama Izadpanah1, Parastoo Shabani1, Ali Aghebati-Maleki1,2
1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
Osteosarcoma (OS) is one of the most common bone tumors in children and adolescents that cause a high rate of mortality in this age group and tends to be metastatic, in spite of chemotherapy and surgery. The main reason for this can be returned to a small group of malignant cells called cancer stem cells (CSCs). OS-CSCs play a key role in the resistance to treatment and relapse and metastasis through self-renewal and differentiation abilities. In this review, we intend to go through the different aspects of this malignant disease, including the cancer stem cell-phenotype, methods for isolating CSCs, signaling pathways, and molecular markers in this disease, and drugs showing resistance in treatment efforts of OS.
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