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Updated: Jan 4, 2026
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
Published on: October 18, 2011
A Hypothesis-Generating Study Using Electrophysiology to Examine Cognitive Function in Colon Cancer Patients
Stanley Hughwa Hung1, Sumeet Mutti Jaswal2, Sarah Elizabeth Neil-Sztramko3
1Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Introduction:
The purpose of this study was to describe the trajectory of cognitive function using neuropsychological tests and electrophysiological measures in individuals receiving 5FU/oxaliplatin chemotherapy for colon cancer.
Methods:
A total of 10 participants were tested at baseline (within 3 weeks of starting chemotherapy), 6 months (coinciding with the end of chemotherapy treatment), and 12 months (approximately 6 months post-chemotherapy). Participants completed neuropsychological tests and electrophysiology recordings of P300 event-related potential (ERP) elicited by a sustained attention to response task paired with experience sampling of attentional states (subjective reports of on-task or mind wandering).
Results:
No change in mean neuropsychological test performance was observed. Comparison of mean P300 ERP amplitudes as a function of attentional states (on-task vs. mind wandering) revealed no main effect of attentional state observed at baseline or 6 months, but a significant effect of attention was observed at 12 months, consistent with effects observed in healthy individuals.
Conclusions:
Future studies can consider sustained attention constructs when studying cognitive function in colon cancer patients.
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