Related Experiment Video

Updated: Jan 4, 2026

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
06:06

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

2.0K

Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae causing invasive diseases in China: a

Jinjian Fu1,2, Rongsong Yi3, Yongjiang Jiang4

  • 1Department of Laboratory Medicine, Liuzhou Maternity and Child Health Care Hospital, Liuzhou, 545001, Guangxi, China.

BMC Pediatrics
|November 13, 2019
PubMed

Insights

Invasive pneumococcal disease (IPD) in China is primarily caused by serotypes 19F, 19A, and 14. The pneumococcal conjugate vaccine PCV13 covers 90% of these serotypes, offering significant health benefits for children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Invasive pneumococcal disease (IPD) poses a significant threat to children's health globally.
  • Understanding the epidemiology of IPD, including prevalent serotypes and antibiotic resistance patterns, is crucial for effective prevention and control strategies.

Purpose of the Study:

  • To systematically review and summarize the available data on IPD in children in mainland China.
  • To identify the predominant Streptococcus pneumoniae serotypes and assess their antibiotic resistance profiles.
  • To evaluate the potential impact of pneumococcal conjugate vaccines (PCVs) in the Chinese context.

Main Methods:

  • A systematic review of 16 eligible studies was conducted.
  • A random-effects model was employed to estimate the pooled prevalence of IPD.
  • Serotype distribution, vaccine coverage, and antibiotic resistance rates were analyzed.

Main Results:

  • The most prevalent serotypes were 19F (27.7%), 19A (21.2%), and 14 (16.5%).
  • Pneumococcal conjugate vaccine PCV13 demonstrated 90% serotype coverage.
  • High rates of antibiotic resistance were observed, with 32.0% resistance to penicillin and over 90% resistance to erythromycin and clindamycin.

Conclusions:

  • PCV13 exhibits high coverage for the predominant serotypes causing IPD in Chinese children.
  • The high prevalence of antibiotic-resistant strains underscores the importance of vaccination.
  • Implementing PCV13 into China's Expanded Program on Immunizations (EPI) is recommended to improve public health outcomes.
Abstract

Keywords:
ChildrenChinaInvasive pneumococcal diseaseSerotypeStreptococcus pneumonia

More Related Videos

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination09:11

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

Published on: September 25, 2014

22.5K
Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae09:12

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae

Published on: January 17, 2014

13.0K

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
673
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
739
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.8K