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Related Concept Videos

Genetic Screens02:46

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Value-based genomic screening: exploring genomic screening for chronic diseases using triple value principles.

Viktor Dombrádi1, Erica Pitini2, Carla G van El3

  • 1Department of Health Systems Management and Quality Management for Health Care, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.

BMC Health Services Research
|November 13, 2019
PubMed
Summary

Triple value principles aid healthcare professionals in evaluating genomic screening. This framework helps balance costs, benefits, and patient preferences for effective chronic disease management.

Keywords:
Chronic diseaseGenomicsPreventionScreeningValue-based healthcare

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Area of Science:

  • Genomic Medicine
  • Health Services Research
  • Bioethics

Background:

  • Genomic screening implementation faces challenges in scalability and resource allocation.
  • Improper evaluation of genomic screening costs, benefits, and tradeoffs risks healthcare waste and patient harm.

Purpose of the Study:

  • To explore how triple value principles can guide healthcare professionals in genomic screening decisions.
  • To minimize waste, maximize benefits, and incorporate patient-centered outcomes in genomic screening.

Main Methods:

  • Applying allocative value to optimize resource distribution for population health benefits and cost-effectiveness.
  • Utilizing technical value to ensure appropriate genomic interventions are selected and delivered effectively.
  • Incorporating personal value through informed patient decision-making based on individual preferences and values.

Main Results:

  • Triple value principles offer a framework for assessing complex decisions in genomic screening.
  • This approach aids in navigating tradeoffs between population-level benefits and individual patient needs.
  • Methods like ACCE, HTA, and screening criteria support the identification of suitable genomic applications.

Conclusions:

  • Triple value principles empower healthcare professionals to make informed judgments on genomic screening for chronic diseases.
  • This framework supports the integration of genomic screening to improve patient and population health outcomes.
  • Reasoned decision-making is crucial for maximizing the value of genomic screening in healthcare systems.