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Association of N6-methyladenosine with viruses and related diseases

Fang Wu1,2, Wenzhao Cheng3,4, Feiyuan Zhao1,2

  • 1Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University, Xiamen, China.

Virology Journal
|November 13, 2019
PubMed
Abstract

Insights

N6-methyladenosine (m6A) modification regulates gene expression and is implicated in viral infections. Understanding the m6A-virus relationship offers new therapeutic strategies for viral diseases.

Area of Science:

  • Molecular Biology
  • Virology
  • Epigenetics

Background:

  • N6-methyladenosine (m6A) is the most common internal modification in eukaryotic mRNA.
  • m6A regulates gene expression through writers, erasers, and readers, impacting RNA metabolism.
  • m6A plays a role in RNA folding, stability, splicing, nuclear export, translation, and degradation.

Purpose of the Study:

  • To review the role of m6A in the viral lifecycle.
  • To explore m6A's contribution to the pathogenesis of human diseases caused by viruses.
  • To highlight viruses like HIV-1, IAV, HBV, HCV, and EBV where m6A is implicated.

Main Methods:

  • Literature review of studies on m6A modification in viruses.
  • Analysis of m6A's impact on viral gene expression and replication.
  • Synthesis of current knowledge on m6A-virus interactions.

Main Results:

  • Abnormal m6A modification is linked to aberrant expression of viral genes.
  • m6A influences multiple stages of viral replication and pathogenesis.
  • Specific viruses like HIV-1, IAV, HBV, HCV, and EBV demonstrate significant m6A involvement.

Conclusions:

  • Understanding the m6A-virus relationship provides insights into viral replication and disease pathogenesis.
  • m6A's role in disease-causing viruses suggests novel therapeutic targets.
  • Further research into m6A modification could lead to new treatments for viral infections.
Keywords:
DemethylasesMethyltransferasesN6-methyladenosine (m6A)Viral diseasesm6A-binding proteins

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