Related Experiment Video
Updated: Jan 4, 2026
04:22
Author Spotlight: Advancing Human Cardiac Anatomy Through Multi-Scale Analysis of Hearts
Published on: June 28, 2024
865
Modelling towards a more holistic medicine: The Virtual Physiological Human (VPH)
1Laboratory of Anatomy, Biomechanics and Organogenesis, Faculty of Medicine, Université Libre de Bruxelles, Belgium; Center for Functional Evaluation, Erasme Hospital, Université Libre de Bruxelles, Belgium.
Morphologie : Bulletin De L'Association Des Anatomistes
|November 13, 2019
Summary
The Virtual Physiological Human (VPH) initiative creates a framework for collaborative research on the human body as a complex system. It enables integrated computer models of human functions by sharing data and resources.
Area of Science:
- Physiological modeling
- Computational biology
- Systems biology
Background:
- The Virtual Physiological Human (VPH) initiative is a European effort building on the international Physiome initiative.
- It aims to create a shared framework for studying the human body as an integrated system.
Discussion:
- The VPH framework facilitates resource and data sharing among institutions.
- It supports the development of diverse, yet interconnected, computational models.
Key Insights:
- The initiative enables the integration of heterogeneous data sources into mechanistic computer models.
- It covers mechanical, physical, and biochemical functions across most anatomical systems.
Outlook:
- The VPH framework is foundational for advancing systems-level understanding of human physiology.
- It promotes collaborative, data-driven approaches in biomedical research.
Related Concept Videos
01:09Clearance Models: Physiological Models
258
Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
258
01:15Model Approaches for Pharmacokinetic Data: Physiological Models
229
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
229
01:18Models of Health Promotion and Illness Prevention II
2.0K
The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results...
The agent-host-environment model states that disease results...
2.0K
01:25Models of Health Promotion and Illness Prevention I
2.6K
A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
2.6K
01:20Pharmacokinetic Models: Overview
1.8K
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
1.8K
01:07Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
234
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
A recent model describes pravastatin's hepatobiliary excretion,...
234