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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

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Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Allergen immunotherapy (AIT) in asthma.

J Christian Virchow1

  • 1Departments of Pneumology / Intensive Care Medicine, Universitätsmedizin Rostock, Ernst-Heydemann Strasse 6, 18055 Rostock, Germany.

Seminars in Immunology
|November 13, 2019
PubMed
Summary

Allergen immunotherapy (AIT) shows promise in managing asthma symptoms and reducing medication needs. Recent studies suggest AIT may offer benefits comparable to inhaled corticosteroids and aid in preventing asthma development.

Keywords:
AITAllergen immunotherapyAllergic rhinitisAsthmaTreatment

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Area of Science:

  • Immunology
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Bronchial asthma is a prevalent chronic respiratory disease with significant morbidity and mortality.
  • Current treatments focus on symptom management, with limited disease-modifying options like allergen immunotherapy (AIT).
  • The exact mechanisms and clinical efficacy of AIT in asthma remain under investigation.

Purpose of the Study:

  • To evaluate the clinical effectiveness of allergen immunotherapy (AIT) in asthma management.
  • To assess AIT's potential role in the secondary prevention of asthma.
  • To clarify the immunological mechanisms underlying AIT's benefits in asthma.

Main Methods:

  • Review of recent large-scale, dose-ranging studies with standardized allergens.
  • Analysis of patient-relevant endpoints, including corticosteroid use and exacerbations after inhaled corticosteroid (ICS) withdrawal.
  • Examination of studies investigating AIT in at-risk populations for asthma prevention.

Main Results:

  • Recent robust studies corroborate AIT's clinical benefits in asthma control, potentially reducing the need for inhaled corticosteroids (ICS).
  • AIT demonstrates potential in reducing allergen-specific and non-specific bronchial hyperresponsiveness.
  • Evidence suggests AIT may play a role in the secondary prevention of asthma in at-risk individuals.

Conclusions:

  • Allergen immunotherapy (AIT) is a viable therapeutic option for asthma, potentially offering controller effects similar to ICS.
  • AIT shows promise in the secondary prevention of asthma in susceptible populations.
  • Further research on long-term effects and comparative studies is necessary to solidify AIT's role in asthma prevention and control.