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Related Concept Videos

Neurulation01:30

Neurulation

44.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
44.9K

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Neurogenesis Using P19 Embryonal Carcinoma Cells
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Neuroblastoma in a Neonate: A Case Report.

Amy J Jnah, Shawna Kristey Evans, Kerry Sewell

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    Neuroblastoma is a common neonatal solid tumor caused by oncogene mutations. Early identification and tailored treatments, including immunotherapy, improve outcomes for this rare childhood cancer.

    Keywords:
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    Area of Science:

    • Pediatric Oncology
    • Cancer Genetics

    Background:

    • Neuroblastoma is a prevalent solid tumor in neonates, accounting for 6-10% of childhood cancers.
    • It arises from abnormal neural crest cell proliferation due to oncogene mutations.
    • Clinical signs include blueberry rash and subcutaneous nodules; histology shows small, round, blue cell tumors.

    Observation:

    • Cytogenetic testing is crucial for distinguishing aggressive from non-aggressive neuroblastoma.
    • Treatment strategies vary from supportive care to surgery, chemotherapy, and novel targeted therapies.
    • Patient outcomes depend significantly on age at diagnosis and specific genetic abnormalities.

    Findings:

    • This article reviews the current scientific understanding of metastatic familial (congenital) neuroblastoma.
    • It includes a case report to illustrate key aspects of the disease.
    • Advances in molecular therapies and immunotherapy offer personalized treatment approaches.

    Implications:

    • Neonatal clinicians require up-to-date knowledge for early detection and management of neuroblastoma.
    • Understanding genetic factors is key to predicting neuroblastoma prognosis and treatment response.
    • Further research into targeted therapies and immunotherapy is vital for improving survival rates.