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Reoperation for brain metastases.

N Sundaresan1, V P Sachdev, G V DiGiacinto

  • 1St Luke's-Roosevelt Hospital Center, New York, NY.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|October 1, 1988
PubMed
Summary
This summary is machine-generated.

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Repeat surgery for brain metastases offers significant benefits. Reoperation improved neurological function in most patients and provided a median survival of 9 months, with no surgical mortality.

Area of Science:

  • Neurosurgery
  • Oncology
  • Neurology

Background:

  • Brain metastases are a common complication of systemic cancer.
  • Surgical resection is a primary treatment for single, accessible brain metastases.
  • Tumor recurrence necessitates further therapeutic strategies.

Purpose of the Study:

  • To evaluate the safety and efficacy of reoperation for recurrent brain metastases.
  • To assess survival outcomes and neurological improvement following repeat craniotomy.
  • To identify patient selection criteria for repeat surgical intervention.

Main Methods:

  • Retrospective analysis of 21 patients undergoing reoperation for recurrent brain metastases.
  • Categorization of recurrence patterns: local vs. distant brain sites.

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  • Assessment of survival, neurological status, and surgical complications.

    • Main Results:

    • Median survival post-reoperation was 9 months, with a 2-year actuarial survival of 25%.
    • Two-thirds of patients experienced neurological improvement, lasting a median of 6 months.
    • No mortality occurred, and only one patient had an increased neurological deficit.

    Conclusions:

    • Repeat resection of brain metastases is a viable therapeutic option for selected patients.
    • Symptomatic patients with accessible recurrent lesions should be considered for reoperation.
    • Reoperation can improve quality of life and survival before experimental treatments.