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Cancer Risk in Collagenous Colitis
Johanna K Larsson1, Konstantinos J Dabos2, Peter Höglund3
1Department of Gastroenterology, Skåne University Hospital, 205 02 Malmö, Sweden.
Journal of Clinical Medicine
|November 14, 2019
Summary
Patients with collagenous colitis (CC) have an increased risk of lung, bladder, and non-melanoma skin cancers. However, the risk for colon cancer was found to be decreased in a Swedish cohort.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Malignancy data in collagenous colitis (CC) patients is limited.
- Understanding cancer incidence in CC is crucial for patient management.
Purpose of the Study:
- To determine the incidence of various cancers in patients diagnosed with collagenous colitis.
- To assess the cancer risk associated with collagenous colitis.
Main Methods:
- An observational, two-stage study utilizing data from two cohorts diagnosed between 2000-2015.
- Cancer risk calculated using age-standardized rates and standardized incidence ratios.
- Involved cohorts from Scotland and Sweden, with a focus on a second Swedish cohort for specific analyses.
Main Results:
- Increased incidence rates observed for lung cancer (RR 3.9), bladder cancer (RR 9.2), and non-melanoma skin cancer (NMSC) (RR 15) in the first cohort.
- The second Swedish cohort showed a markedly increased risk for cutaneous squamous cell carcinoma (SIR 3.27).
- A decreased risk for colon cancer (SIR 0.23) was noted in the second Swedish cohort.
Conclusions:
- Collagenous colitis is associated with an elevated risk for specific cancers, notably lung, bladder, and non-melanoma skin cancers.
- Further research is warranted to elucidate the mechanisms behind these associations and guide clinical surveillance strategies.
Keywords:
cancer riskcollagenous colitiscolon cancerlung cancermicroscopic colitisskin cancersquamous cell carcinomaMore Related Videos
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