Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Scaling up polarization-sensitive optical coherence tomography to image the whole macaque brain.

bioRxiv : the preprint server for biology·2026

Same author

Replicability of multivariate brain-behaviour associations depends on clinical profile.

Communications biology·2026

Same author

Lip-reading and eye-gaze discrimination are functionally lateralized across the left and right posterior superior temporal sulci.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same author

Short-Term Developmental Trajectories of Dorsal-Ventral Pathways and Their Relationships with First-Grade Learning.

bioRxiv : the preprint server for biology·2026

Same author

From inflammation to neurodegeneration: an exploratory pilot study of a diagnostic framework for progression in MS.

Frontiers in neurology·2026

Same author

Human white matter tracts aligned with canonical functional brain networks.

bioRxiv : the preprint server for biology·2026

Same journal

Within-subject alterations in CSF and blood flow dynamics following rhythm-control intervention in atrial fibrillation: An exploratory multimodal MRI study.

NeuroImage. Clinical·2026

Same journal

Diffusion MRI of white matter alterations in chronic traumatic brain injury: a systematic review and meta-analysis.

NeuroImage. Clinical·2026

Same journal

Decoding functional changes in the brain following ischemic stroke: a multimodal feature approach integrating fNIRS with machine learning and deep learning.

NeuroImage. Clinical·2026

Same journal

Structural brain alterations in chronic primary pain: a multimodal MRI study.

NeuroImage. Clinical·2026

Same journal

Using functional MRI neurofeedback to modulate self-blame in major depressive disorder: A pilot study.

NeuroImage. Clinical·2026

Same journal

Language network reorganization in temporal lobe epilepsy: insights from task-based functional MRI.

NeuroImage. Clinical·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 3, 2026

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Published on: September 4, 2021

Quantifying nerve decussation abnormalities in the optic chiasm.

Robert J Puzniak¹, Khazar Ahmadi¹, Jörn Kaufmann²

¹Department of Ophthalmology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.

Neuroimage. Clinical

|November 14, 2019

Summary

This summary is machine-generated.

Diffusion MRI (dMRI) reveals abnormal optic chiasm fiber crossing in albinism. This advanced imaging technique aids in diagnosing visual pathway abnormalities.

Keywords:

Albinism Crossing nerves Diffusion MRI Functional MRI Optic chiasm

More Related Videos

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Published on: August 18, 2023

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Related Experiment Videos

Last Updated: Jan 3, 2026

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Published on: September 4, 2021

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Published on: August 18, 2023

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Area of Science:

Neuroimaging
Neuroscience
Ophthalmology

Background:

The human optic chiasm contains partially crossing optic nerve fibers.
Albinism is associated with an abnormally high proportion of crossing fibers in the optic chiasm.

Purpose of the Study:

To use in-vivo diffusion MRI (dMRI) to identify and quantify the abnormally high proportion of crossing fibers in the optic chiasm of individuals with albinism.
To compare the discriminative power of different dMRI signal modeling and tractography methods for detecting these abnormalities.

Main Methods:

Acquired high-resolution 3T dMRI data from 9 individuals with albinism and 8 controls.
Analyzed data using Diffusion Tensor (DT) and Constrained Spherical Deconvolution (CSD) modeling, tractography, and streamline filtering (LiFE, COMMIT, SIFT2).
Cross-validated dMRI results with fMRI estimates of misrouting in a subset of participants.

Main Results:

Detected significant group differences in chiasmal crossing for both DT and CSD tractograms.
AUC measures indicated strong discriminative power for DT (0.61) and CSD (0.75).
dMRI and fMRI estimates of crossing strengths were significantly correlated for CSD (R²=0.83).

Conclusions:

Streamline filtering combined with optimized probabilistic tracking improves the detection of optic chiasm crossing.
CSD-based tractography is an efficient approach for detecting structural abnormalities in the optic chiasm.
This study presents a novel anatomy-driven approach for individualized diagnostics of optic chiasm abnormalities.