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Updated: Jan 3, 2026

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Published on: July 26, 2017
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TNFAIP8: Inflammation, Immunity and Human Diseases
Suryakant Niture1, John Moore1, Deepak Kumar1
1Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University Durham, NC 27707, USA.
Summary
Tumor necrosis factor-alpha-induced protein 8 (TNFAIP8) is a key TIPE family protein. This review explores TNFAIP8
Area of Science:
- Immunology
- Cellular Biology
- Molecular Biology
Background:
- The Tumor Necrosis Factor (TNF)-alpha-induced protein 8 (TNFAIP8 / TIPE) family plays a crucial role in immune homeostasis.
- This family comprises four members: TNFAIP8, TIPE1, TIPE2, and TIPE3.
Purpose of the Study:
- To review the latest research on the roles and associations of TNFAIP8.
- To highlight TNFAIP8's involvement in cellular functions, signaling pathways, inflammation, and immune-related human diseases.
Main Methods:
- Literature review of recent studies on TNFAIP8.
- Analysis of TNFAIP8's functions in cellular processes.
- Examination of TNFAIP8's role in inflammatory and immune responses.
Main Results:
- TNFAIP8 is a founding member of the TIPE family with diverse cellular functions.
- TNFAIP8 is implicated in regulating inflammation and immune responses.
- Associations between TNFAIP8 and various human diseases are emerging.
Conclusions:
- TNFAIP8 is a significant protein with multifaceted roles in cellular signaling, inflammation, and immunity.
- Further research into TNFAIP8's functions can provide insights into immune-related diseases.
- TNFAIP8 represents a potential therapeutic target for inflammatory and immune disorders.
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