Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

9.7K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
9.7K
T Cell Types and Functions01:24

T Cell Types and Functions

2.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.0K
Inflammatory Response01:28

Inflammatory Response

15.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.8K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

414
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
414
Inflammation01:38

Inflammation

61.3K
Overview
61.3K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

8.5K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concurrent Methicillin-Resistant <i>Staphylococcus aureus Septicemia</i> and Thyroid Abscess in a Young Male with Dengue.

Infectious disorders drug targets·2020
Same author

TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation.

Cell death & disease·2020
Same author

SHORTROOT-Mediated Intercellular Signals Coordinate Phloem Development in Arabidopsis Roots.

The Plant cell·2020
Same author

Hypercalcemic Encephalopathy as an Initial Presentation of Multiple Myeloma.

Case reports in emergency medicine·2020
Same author

NMR-derived targeted serum metabolic biomarkers appraisal of bladder cancer: A pre- and post-operative evaluation.

Journal of pharmaceutical and biomedical analysis·2020
Same author

Self-Reported Burden in Elderly Patients With Localized Prostate Cancer Treated With Stereotactic Body Radiation Therapy (SBRT).

Frontiers in oncology·2020

Related Experiment Video

Updated: Jan 3, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.9K

TNFAIP8: Inflammation, Immunity and Human Diseases.

Suryakant Niture1, John Moore1, Deepak Kumar1

  • 1Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University Durham, NC 27707, USA.

Journal of Cellular Immunology
|November 15, 2019
PubMed
Summary

Tumor necrosis factor-alpha-induced protein 8 (TNFAIP8) is a key TIPE family protein. This review explores TNFAIP8

Area of Science:

  • Immunology
  • Cellular Biology
  • Molecular Biology

Background:

  • The Tumor Necrosis Factor (TNF)-alpha-induced protein 8 (TNFAIP8 / TIPE) family plays a crucial role in immune homeostasis.
  • This family comprises four members: TNFAIP8, TIPE1, TIPE2, and TIPE3.

Purpose of the Study:

  • To review the latest research on the roles and associations of TNFAIP8.
  • To highlight TNFAIP8's involvement in cellular functions, signaling pathways, inflammation, and immune-related human diseases.

Main Methods:

  • Literature review of recent studies on TNFAIP8.
  • Analysis of TNFAIP8's functions in cellular processes.
  • Examination of TNFAIP8's role in inflammatory and immune responses.

Main Results:

Keywords:
ImmunityInflammationTNFAIP8

More Related Videos

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
09:56

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Published on: March 2, 2016

10.8K
Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1&#946; in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

21.3K

Related Experiment Videos

Last Updated: Jan 3, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.9K
Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
09:56

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Published on: March 2, 2016

10.8K
Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1&#946; in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

21.3K
  • TNFAIP8 is a founding member of the TIPE family with diverse cellular functions.
  • TNFAIP8 is implicated in regulating inflammation and immune responses.
  • Associations between TNFAIP8 and various human diseases are emerging.

Conclusions:

  • TNFAIP8 is a significant protein with multifaceted roles in cellular signaling, inflammation, and immunity.
  • Further research into TNFAIP8's functions can provide insights into immune-related diseases.
  • TNFAIP8 represents a potential therapeutic target for inflammatory and immune disorders.