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Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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Antimicrobial Proteins01:23

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
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Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
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Antimicrobial resistance: A multifaceted problem with multipronged solutions.

Teresa Gil-Gil1, Pablo Laborda1, Fernando Sanz-García1

  • 1Centro Nacional de Biotecnología CSIC, Madrid, Spain.

Microbiologyopen
|November 15, 2019
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Antimicrobial resistance is a growing threat. New research explores its causes, spread, and solutions, offering vital insights to combat infectious diseases and improve public health outcomes.

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Global HealthInfectious diseasesOne Healthantibiotic resistance

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Infectious diseases remain a significant global health burden.
  • The escalating crisis of antimicrobial resistance (AMR) exacerbates this challenge.
  • Understanding AMR's emergence and spread is crucial for effective intervention.

Purpose of the Study:

  • To present a collection of articles addressing the multifaceted nature of antimicrobial resistance.
  • To provide novel information for comprehending and combating AMR.
  • To highlight the need for further research into AMR causes, routes, and reservoirs.

Main Methods:

  • This special issue compiles diverse research articles.
  • Studies analyze various aspects of antimicrobial resistance.
  • Methodologies likely include epidemiological, microbiological, and potentially clinical research approaches.

Main Results:

  • The presented articles offer new data on antimicrobial resistance.
  • Findings contribute to a deeper understanding of AMR phenomena.
  • The collection underscores the complexity of AMR and the need for integrated strategies.

Conclusions:

  • Addressing antimicrobial resistance requires comprehensive research and strategic interventions.
  • Continued investigation into AMR's origins and transmission is essential.
  • This special issue provides valuable resources for scientists and public health professionals working to mitigate AMR.