Association of Valproic Acid With Central Sleep Apnea Syndrome: Two Case Reports

Kelly Guichard1, Jean-Arthur Micoulaud-Franchi, Aileen McGonigal

  • 1Clinique du Sommeil, Bordeaux University Hospital (CHU), and Université de Bordeaux and CNRS, SANPSY, USR 3413, Bordeaux, France kelly.guichard@gmail.com Clinique du Sommeil, Bordeaux University Hospital (CHU), and Université de Bordeaux and CNRS, SANPSY, USR 3413, Bordeaux, France Aix Marseille Univ, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France Clinique du Sommeil, Bordeaux University Hospital (CHU), Bordeaux, France Clinique du Tondu, Bordeaux, France Département de Neurophysiologie Clinique, Pôle Neurosciences Cliniques, CHU de Bordeaux and Université de Bordeaux, Institut de Neurosciences, Cognitives et Intégratives d'Aquitaine, UMR 5287, Bordeaux, France Bordeaux Population Health Research Center, Pharmacoepidemiology Team (UMR 1219), INSERM, University of Bordeaux, Bordeaux, France Clinique du Sommeil, Bordeaux University Hospital (CHU) and Université de Bordeaux and CNRS, SANPSY, USR 3413, Bordeaux, France.

Abstract

No abstract available in PubMed .

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
424
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
344
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
1.2K
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
466
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.1K
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
437