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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Related Experiment Video

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Doppler Optical Coherence Tomography of Retinal Circulation
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Simultaneous Morphological and Flow Imaging Enabled by Megahertz Intravascular Doppler Optical Coherence Tomography.

Tianshi Wang, Tom Pfeiffer, Joost Daemen

    IEEE Transactions on Medical Imaging
    |November 15, 2019
    PubMed
    Summary

    We developed a new 3D intravascular flow imaging technique using megahertz (MHz) Optical Coherence Tomography (OCT). This method enables high-speed, detailed visualization of blood flow and vessel structure in real-time clinical workflows.

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    Area of Science:

    • Medical Imaging
    • Biomedical Engineering
    • Cardiovascular Technology

    Background:

    • Intravascular imaging is crucial for diagnosing cardiovascular diseases.
    • Current methods often lack the speed and resolution for comprehensive flow analysis.
    • Optical Coherence Tomography (OCT) offers high-resolution imaging but struggles with fast flow quantification.

    Purpose of the Study:

    • To develop and validate a 3D intravascular Doppler Optical Coherence Tomography (OCT) system for clinical compatibility.
    • To enable simultaneous high-speed 3D morphological and Doppler flow imaging.
    • To improve the assessment of coronary artery blood flow dynamics.

    Main Methods:

    • Utilized a megahertz (MHz) Fourier Domain Mode Locked (FDML) laser and a 1.1 mm motorized catheter for OCT imaging.
    • Implemented a post-processing method to compensate for laser drift and resolve Doppler phase shifts.
    • Achieved high frame rates (600 frames/s) and pullback speeds (40 mm/s) for volumetric data acquisition.

    Main Results:

    • Demonstrated real-time 3D intravascular flow imaging with MHz OCT.
    • Successfully measured flow velocities up to 37.5 cm/s without phase-unwrapping.
    • Presented the first simultaneous 3D morphological images and Doppler flow profiles.
    • Enabled flow pattern estimation and 3D structural reconstruction from a single pullback dataset.

    Conclusions:

    • The developed MHz OCT system provides a clinically compatible platform for advanced 3D intravascular flow imaging.
    • This technology significantly enhances the ability to visualize and analyze coronary artery hemodynamics.
    • Offers a powerful tool for improved diagnosis and treatment planning in cardiovascular medicine.