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Design of Coenzyme Q10 solid dispersion for improved solubilization and stability
Jin-Seok Choi1, Ji-Won Park2, Jeong-Sook Park3
1Department of Medical Management, Chodang University, 380 Muan-ro, Muan-eup, Muan-gun, Jeollanam-do 58530, Republic of Korea.
International Journal of Pharmaceutics
|November 15, 2019
Summary
A novel Coenzyme Q10 (CQ10) solid dispersion formulation significantly enhances drug solubility and stability. This improved CQ10 delivery system shows promise for treating age-related and cardiovascular diseases.
Area of Science:
- Pharmaceutical Science
- Drug Delivery Systems
Background:
- Poorly soluble drugs present significant challenges in pharmaceutical development.
- Enhancing solubility, dissolution, and stability of Coenzyme Q10 (CQ10) is crucial for its therapeutic efficacy.
Purpose of the Study:
- To develop a Coenzyme Q10 (CQ10) solid dispersion (SD) formulation with improved solubility, dissolution, and stability.
- To optimize the CQ10 SD formulation using a dual polymer system and evaluate its physicochemical properties.
Main Methods:
- Coenzyme Q10 (CQ10) solid dispersions (SD) were prepared using a melting method with a dual polymer system.
- Poloxamer 407 (Kolliphor® P407) and polyvinylpyrrolidone (Kollidon® 17) were selected as solubilizer and co-solubilizer, respectively.
- Aerosil® 200 was utilized as the carrier, and the SD7 formulation (CQ10:Aerosil®200:P407®:K17® = 1:4:4:1) was optimized.
Main Results:
- The optimized SD7 formulation demonstrated a significant enhancement in dissolution (29- to 95-fold) across different pH conditions compared to commercial products.
- The SD7 formulation exhibited superior stability over 9 months of storage at room temperature.
- Physicochemical properties of the SD formulations were thoroughly evaluated.
Conclusions:
- A Coenzyme Q10 (CQ10) solid dispersion formulation (SD7) was successfully developed with markedly improved dissolution and stability.
- The developed SD7 formulation is anticipated to enhance bioavailability and therapeutic effectiveness for aging-related and cardiovascular conditions.
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