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The psychopharmacology of pseudobulbar affect
Linda Nguyen1, Rae R Matsumoto2
1Departments of Neurosciences and Pediatrics, University of California San Diego, San Diego, CA, United States.
Abstract:
Pseudobulbar affect (PBA) is characterized by uncontrollable emotional episodes disconnected or disproportionate with mood, in association with an array of neurologic conditions. PBA is associated with disruption of descending control of brainstem motor circuitry and dysregulation of serotonergic and glutamatergic function. PBA has been historically under recognized, though advances resulting in more specific diagnostic criteria, validated rating scales, and an approved pharmacotherapy offer opportunities for improved treatment outcomes.
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