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Biomarkers in pediatric acute respiratory distress syndrome

Erin F Carlton1, Heidi R Flori1

  • 1Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.

Annals of Translational Medicine
|November 16, 2019
PubMed

Insights

Biomarkers offer potential for diagnosing pediatric acute respiratory distress syndrome (PARDS), predicting patient outcomes, and guiding targeted therapies for this severe lung injury. Further research into PARDS biomarkers is crucial for personalized treatment strategies.

Area of Science:

  • Critical Care Medicine
  • Pediatric Pulmonology
  • Biomarker Research

Background:

  • Pediatric acute respiratory distress syndrome (PARDS) is a severe, heterogeneous lung injury lacking single diagnostic indicators.
  • Current PARDS diagnosis relies on combined clinical and physiological variables, with limited predictive capabilities for disease trajectory or treatment response.
  • Understanding PARDS pathophysiology and patient subgroups is essential for effective therapeutic strategies.

Purpose of the Study:

  • To review the role and potential of biomarkers in the diagnosis, prognostication, and therapeutic response assessment of PARDS.
  • To explore how biomarkers can enhance the understanding of PARDS heterogeneity and identify specific patient endotypes.
  • To discuss current and future directions in biomarker research for PARDS.

Main Methods:

  • Literature review of existing studies on biomarkers in pediatric acute respiratory distress syndrome.
  • Analysis of the diagnostic, prognostic, and therapeutic implications of various biomarkers.
  • Discussion of the application of biomarkers in stratifying patients and guiding treatment decisions.

Main Results:

  • Biomarkers show significant promise in improving PARDS diagnosis beyond current clinical criteria.
  • Biomarkers can aid in predicting patient outcomes and identifying individuals at high risk for adverse events.
  • Biomarker research is key to understanding PARDS endotypes and personalizing treatment approaches.

Conclusions:

  • Biomarkers are invaluable tools for advancing the understanding and management of pediatric acute respiratory distress syndrome.
  • Further investigation into PARDS biomarkers is critical for developing targeted therapies and improving patient outcomes.
  • Biomarker discovery and validation are essential for precision medicine in pediatric critical care.

Keywords:
Pediatric acute respiratory distress syndrome (PARDS)acute lung injurybiomarkers

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