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Stimuli-Responsive Biomolecule-Based Hydrogels and Their Applications.

Margarita Vázquez-González1, Itamar Willner1

  • 1Institute of Chemistry, Hebrew University of Jerusalem, Jerusalem, 91904, Israel.

Angewandte Chemie (International Ed. in English)
|November 16, 2019
PubMed
Summary

This review explores biomolecule-based hydrogels as adaptable polymer scaffolds. These stimuli-responsive materials offer controlled stiffness for diverse applications, including drug delivery and surface coatings.

Keywords:
DNAdrug releasepolysaccharidesself-healingshape memory

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Supramolecular Chemistry

Background:

  • Biomolecules like polysaccharides, oligosaccharides, nucleic acids, peptides, and proteins can serve as functional polymer scaffolds.
  • Hydrogels are crosslinked polymer networks capable of absorbing large amounts of water.
  • Stimuli-responsive materials change their properties in response to external triggers.

Purpose of the Study:

  • To review the use of biomolecules as stimuli-responsive polymer scaffolds for creating tunable hydrogels.
  • To discuss methods for controlling hydrogel stiffness using physical or chemical triggers.
  • To highlight the applications of these advanced biomaterial systems.

Main Methods:

  • Utilizing polysaccharides, oligosaccharides, nucleic acids, peptides, and proteins as building blocks for hydrogel scaffolds.
  • Employing physical or chemical triggers to alter crosslinking units and hydrogel stiffness.
  • Integrating stimuli-responsive supramolecular complexes and biomolecular units as crosslinkers for hybrid hydrogels.

Main Results:

  • Biomolecule-based hydrogels exhibit controlled stiffness through structural reconfiguration of crosslinking units.
  • Hybrid hydrogels demonstrate reversible transitions between different stiffness states upon triggering.
  • Stimuli-responsive hydrogel films can be assembled on surfaces for various applications.

Conclusions:

  • Biomolecule-based hydrogels offer a versatile platform for developing materials with tunable mechanical properties.
  • These hydrogels show significant potential in applications such as controlled drug release via nanoparticle coating and surface functionalization.