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Systemic Artery Aneurysms and Kawasaki Disease

Qu-Ming Zhao1,2, Chen Chu1,2, Lin Wu1

  • 1Children's Hospital of Fudan University, Shanghai, China; and.

Pediatrics
|November 17, 2019
PubMed

Insights

Systemic artery aneurysms (SAAs) occurred in 14.2% of Kawasaki disease (KD) patients screened. Most SAAs showed significant regression within six months, indicating a favorable short-term outcome.

Area of Science:

  • Cardiology
  • Pediatric Rheumatology
  • Vascular Medicine

Background:

  • Coronary artery aneurysms (CAAs) are a known Kawasaki disease (KD) complication.
  • Data on systemic artery aneurysms (SAAs) in KD are limited in the current era.

Purpose of the Study:

  • To determine the incidence and early outcomes of SAAs in KD patients.
  • To analyze SAA development in relation to CAAs.

Main Methods:

  • Screened 162 KD patients at risk for SAAs using magnetic resonance angiography or peripheral angiography.
  • Analyzed incidence and early outcomes of SAAs from April 2016 to March 2019.

Main Results:

  • SAAs detected in 14.2% of screened KD patients (23/162) at 1 month post-onset.
  • 2% of all KD patients (23/1148) had SAAs; median age at onset was 5 months.
  • 129 SAAs found in 17 arteries; common sites include axillary, common iliac, and brachial arteries. High regression rate (92.9%) observed within 6 months.

Conclusions:

  • SAAs in KD patients have a notable incidence.
  • SAAs demonstrate a high rate of regression during short-term follow-up.
Abstract

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